flt3 construct (Carna Inc)
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94
Structured Review
Carna Inc
flt3 construct
Flt3 Construct, supplied by Carna Inc, used in various techniques. Bioz Stars score: 94/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/flt3+construct/BTN-ABL/pm34038857-112-35-9
Average 94 stars, based on 3 article reviews
Flt3 Construct, supplied by Carna Inc, used in various techniques. Bioz Stars score: 94/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/flt3+construct/BTN-ABL/pm34038857-112-35-9
Average 94 stars, based on 3 article reviews
flt3 construct - by Bioz Stars,
2026-10
94/100 stars
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Related Articles
Construct:Article Title: UNC5293, a potent, orally available and highly MERTK-selective inhibitor Article Snippet: Inhibition of MER receptor tyrosine kinase (MERTK) causes direct tumor cell killing and stimulation of the innate immune response.. Therefore, MERTK has been identified as a therapeutic target in a wide variety of human tumors.. Clinical trials targeting MERTK have recently been initiated, however, none of these drugs are MERTK-specific. Article Title: Highly Selective MERTK Inhibitors Achieved by a Single Methyl Group. Article Snippet: Although all kinases share the same ATP binding pocket, subtle differences in the residues that form the pocket differentiate individual kinases’ affinity for ATP competitive inhibitors.. We have found that by introducing a single methyl group, the selectivity of our MERTK inhibitors over another target, FLT3, was increased up to 1000-fold (compound 31).. Compound 19 was identified as an in vivo tool compound with subnanomolar activity against MERTK and 38-fold selectivity over FLT3 in vitro. |